Regulation of Sleep Quality: Analysis of Gene Expression Using Bulk RNA-seq Data -- Poster by Kayla Thomason, Michelle Godoy-Pena, Malei Guzman, Willow Ledesma Bio11A Fall 25

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__Regulation of Sleep Quality: Analysis of Gene Expression Using Bulk RNA-seq Data FA25
__Regulation of Sleep Quality: Analysis of Gene Expression Using Bulk RNA-seq Data FA25960×540 89.9 KB

What we did

  • We looked through multiple data sets and found specific genes that were expressed in the fly’s copper midgut region which are responsible for the amount of sleep a fly gets as well as the quality of that sleep.

How can you help

  • Gaps include the females from every species tested for these genes. More in depth research must be done in order to find the whole story of these genes in the fly midgut.
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Michelle Godoy-Pena

What I did:

Developed the poster introduction, identified and reviewed research papers linking the two genes, and assisted with the overall poster layout and presentation.

How you can help:

A major gap in our understanding was fully identifying the pathways these genes undergo and the proteins they interact with. Further work could include identifying additional pathways or proteins that interact with those we discussed, particularly in relation to their potential role in sleep quality or regulation. Exploring these pathways became my favorite part of the project. As we kept researching, it became clear that these genes are far more complex than expected and are involved in multiple biological processes across the body.

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Malei Guzman, Co-Author

What I did

I helped my team gather information on our topic. I put together the results section of the final poster with all the gathered information.

How you can help

  • more information on the human orthologs would be a great addition to our research.